diff --git a/tools/interop_matrix/client_matrix.py b/tools/interop_matrix/client_matrix.py
index a98440b3109e652046d92cf9211ad9aca8797251..6129b658793423220457443f35ccf163f2a877ce 100644
--- a/tools/interop_matrix/client_matrix.py
+++ b/tools/interop_matrix/client_matrix.py
@@ -99,6 +99,7 @@ LANG_RELEASE_MATRIX = {
         ('v1.20.0', ReleaseInfo()),
         ('v1.21.4', ReleaseInfo()),
         ('v1.22.0', ReleaseInfo()),
+        ('v1.22.1', ReleaseInfo()),
         ('v1.23.0', ReleaseInfo()),
     ]),
     'go':
@@ -215,6 +216,7 @@ LANG_RELEASE_MATRIX = {
         ('v1.20.0', ReleaseInfo()),
         ('v1.21.4', ReleaseInfo()),
         ('v1.22.0', ReleaseInfo()),
+        ('v1.22.1', ReleaseInfo()),
         ('v1.23.0', ReleaseInfo()),
     ]),
     'node':
@@ -266,6 +268,7 @@ LANG_RELEASE_MATRIX = {
         ('v1.20.0', ReleaseInfo()),
         ('v1.21.4', ReleaseInfo()),
         ('v1.22.0', ReleaseInfo()),
+        ('v1.22.1', ReleaseInfo()),
         ('v1.23.0', ReleaseInfo()),
         # TODO: https://github.com/grpc/grpc/issues/18262.
         # If you are not encountering the error in above issue
@@ -295,6 +298,7 @@ LANG_RELEASE_MATRIX = {
         # See https://github.com/grpc/grpc/issues/18264
         ('v1.21.4', ReleaseInfo()),
         ('v1.22.0', ReleaseInfo()),
+        ('v1.22.1', ReleaseInfo()),
         ('v1.23.0', ReleaseInfo()),
     ]),
     'csharp':
@@ -327,6 +331,7 @@ LANG_RELEASE_MATRIX = {
         ('v1.20.0', ReleaseInfo()),
         ('v1.21.4', ReleaseInfo()),
         ('v1.22.0', ReleaseInfo()),
+        ('v1.22.1', ReleaseInfo()),
         ('v1.23.0', ReleaseInfo()),
     ]),
 }