diff --git a/Makefile b/Makefile
index c16b4ff8ea6bb954104717388bc34a296b733f61..3a21854a1e8685a97cdf45875d15dd7ac049d537 100644
--- a/Makefile
+++ b/Makefile
@@ -95,6 +95,42 @@ LDXX_opt = $(DEFAULT_CXX)
 CPPFLAGS_opt = -O2
 DEFINES_opt = NDEBUG
 
+VALID_CONFIG_asan-trace-cmp = 1
+REQUIRE_CUSTOM_LIBRARIES_asan-trace-cmp = 1
+CC_asan-trace-cmp = clang
+CXX_asan-trace-cmp = clang++
+LD_asan-trace-cmp = clang
+LDXX_asan-trace-cmp = clang++
+CPPFLAGS_asan-trace-cmp = -O0 -fsanitize-coverage=edge -fsanitize-coverage=trace-cmp -fsanitize=address -fno-omit-frame-pointer -Wno-unused-command-line-argument -DGPR_NO_DIRECT_SYSCALLS
+LDFLAGS_asan-trace-cmp = -fsanitize=address
+
+VALID_CONFIG_dbg = 1
+CC_dbg = $(DEFAULT_CC)
+CXX_dbg = $(DEFAULT_CXX)
+LD_dbg = $(DEFAULT_CC)
+LDXX_dbg = $(DEFAULT_CXX)
+CPPFLAGS_dbg = -O0
+DEFINES_dbg = _DEBUG DEBUG
+
+VALID_CONFIG_asan = 1
+REQUIRE_CUSTOM_LIBRARIES_asan = 1
+CC_asan = clang
+CXX_asan = clang++
+LD_asan = clang
+LDXX_asan = clang++
+CPPFLAGS_asan = -O0 -fsanitize-coverage=edge -fsanitize=address -fno-omit-frame-pointer -Wno-unused-command-line-argument -DGPR_NO_DIRECT_SYSCALLS
+LDFLAGS_asan = -fsanitize=address
+
+VALID_CONFIG_msan = 1
+REQUIRE_CUSTOM_LIBRARIES_msan = 1
+CC_msan = clang
+CXX_msan = clang++
+LD_msan = clang
+LDXX_msan = clang++
+CPPFLAGS_msan = -O0 -fsanitize-coverage=edge -fsanitize=memory -fsanitize-memory-track-origins -fno-omit-frame-pointer -DGTEST_HAS_TR1_TUPLE=0 -DGTEST_USE_OWN_TR1_TUPLE=1 -Wno-unused-command-line-argument -fPIE -pie -DGPR_NO_DIRECT_SYSCALLS
+LDFLAGS_msan = -fsanitize=memory -DGTEST_HAS_TR1_TUPLE=0 -DGTEST_USE_OWN_TR1_TUPLE=1 -fPIE -pie $(if $(JENKINS_BUILD),-Wl$(comma)-Ttext-segment=0x7e0000000000,)
+DEFINES_msan = NDEBUG
+
 VALID_CONFIG_basicprof = 1
 CC_basicprof = $(DEFAULT_CC)
 CXX_basicprof = $(DEFAULT_CXX)
@@ -121,22 +157,25 @@ LDXX_asan-noleaks = clang++
 CPPFLAGS_asan-noleaks = -O0 -fsanitize-coverage=edge -fsanitize=address -fno-omit-frame-pointer -Wno-unused-command-line-argument -DGPR_NO_DIRECT_SYSCALLS
 LDFLAGS_asan-noleaks = -fsanitize=address
 
-VALID_CONFIG_asan-trace-cmp = 1
-REQUIRE_CUSTOM_LIBRARIES_asan-trace-cmp = 1
-CC_asan-trace-cmp = clang
-CXX_asan-trace-cmp = clang++
-LD_asan-trace-cmp = clang
-LDXX_asan-trace-cmp = clang++
-CPPFLAGS_asan-trace-cmp = -O0 -fsanitize-coverage=edge -fsanitize-coverage=trace-cmp -fsanitize=address -fno-omit-frame-pointer -Wno-unused-command-line-argument -DGPR_NO_DIRECT_SYSCALLS
-LDFLAGS_asan-trace-cmp = -fsanitize=address
+VALID_CONFIG_ubsan = 1
+REQUIRE_CUSTOM_LIBRARIES_ubsan = 1
+CC_ubsan = clang
+CXX_ubsan = clang++
+LD_ubsan = clang
+LDXX_ubsan = clang++
+CPPFLAGS_ubsan = -O0 -fsanitize-coverage=edge -fsanitize=undefined,unsigned-integer-overflow -fno-omit-frame-pointer -Wno-unused-command-line-argument -Wvarargs
+LDFLAGS_ubsan = -fsanitize=undefined,unsigned-integer-overflow
+DEFINES_ubsan = NDEBUG
 
-VALID_CONFIG_dbg = 1
-CC_dbg = $(DEFAULT_CC)
-CXX_dbg = $(DEFAULT_CXX)
-LD_dbg = $(DEFAULT_CC)
-LDXX_dbg = $(DEFAULT_CXX)
-CPPFLAGS_dbg = -O0
-DEFINES_dbg = _DEBUG DEBUG
+VALID_CONFIG_tsan = 1
+REQUIRE_CUSTOM_LIBRARIES_tsan = 1
+CC_tsan = clang
+CXX_tsan = clang++
+LD_tsan = clang
+LDXX_tsan = clang++
+CPPFLAGS_tsan = -O0 -fsanitize=thread -fno-omit-frame-pointer -Wno-unused-command-line-argument -DGPR_NO_DIRECT_SYSCALLS
+LDFLAGS_tsan = -fsanitize=thread
+DEFINES_tsan = GRPC_TSAN
 
 VALID_CONFIG_stapprof = 1
 CC_stapprof = $(DEFAULT_CC)
@@ -164,52 +203,22 @@ CPPFLAGS_memcheck = -O0
 LDFLAGS_memcheck = -rdynamic
 DEFINES_memcheck = _DEBUG DEBUG
 
-VALID_CONFIG_asan = 1
-REQUIRE_CUSTOM_LIBRARIES_asan = 1
-CC_asan = clang
-CXX_asan = clang++
-LD_asan = clang
-LDXX_asan = clang++
-CPPFLAGS_asan = -O0 -fsanitize-coverage=edge -fsanitize=address -fno-omit-frame-pointer -Wno-unused-command-line-argument -DGPR_NO_DIRECT_SYSCALLS
-LDFLAGS_asan = -fsanitize=address
-
-VALID_CONFIG_tsan = 1
-REQUIRE_CUSTOM_LIBRARIES_tsan = 1
-CC_tsan = clang
-CXX_tsan = clang++
-LD_tsan = clang
-LDXX_tsan = clang++
-CPPFLAGS_tsan = -O0 -fsanitize=thread -fno-omit-frame-pointer -Wno-unused-command-line-argument -DGPR_NO_DIRECT_SYSCALLS
-LDFLAGS_tsan = -fsanitize=thread
-DEFINES_tsan = GRPC_TSAN
-
-VALID_CONFIG_ubsan = 1
-REQUIRE_CUSTOM_LIBRARIES_ubsan = 1
-CC_ubsan = clang
-CXX_ubsan = clang++
-LD_ubsan = clang
-LDXX_ubsan = clang++
-CPPFLAGS_ubsan = -O0 -fsanitize-coverage=edge -fsanitize=undefined,unsigned-integer-overflow -fno-omit-frame-pointer -Wno-unused-command-line-argument -Wvarargs
-LDFLAGS_ubsan = -fsanitize=undefined,unsigned-integer-overflow
-DEFINES_ubsan = NDEBUG
-
-VALID_CONFIG_msan = 1
-REQUIRE_CUSTOM_LIBRARIES_msan = 1
-CC_msan = clang
-CXX_msan = clang++
-LD_msan = clang
-LDXX_msan = clang++
-CPPFLAGS_msan = -O0 -fsanitize-coverage=edge -fsanitize=memory -fsanitize-memory-track-origins -fno-omit-frame-pointer -DGTEST_HAS_TR1_TUPLE=0 -DGTEST_USE_OWN_TR1_TUPLE=1 -Wno-unused-command-line-argument -fPIE -pie -DGPR_NO_DIRECT_SYSCALLS
-LDFLAGS_msan = -fsanitize=memory -DGTEST_HAS_TR1_TUPLE=0 -DGTEST_USE_OWN_TR1_TUPLE=1 -fPIE -pie $(if $(JENKINS_BUILD),-Wl$(comma)-Ttext-segment=0x7e0000000000,)
-DEFINES_msan = NDEBUG
+VALID_CONFIG_lto = 1
+CC_lto = $(DEFAULT_CC)
+CXX_lto = $(DEFAULT_CXX)
+LD_lto = $(DEFAULT_CC)
+LDXX_lto = $(DEFAULT_CXX)
+CPPFLAGS_lto = -O3 -flto
+LDFLAGS_lto = -O3 -flto
+DEFINES_lto = NDEBUG
 
 VALID_CONFIG_mutrace = 1
 CC_mutrace = $(DEFAULT_CC)
 CXX_mutrace = $(DEFAULT_CXX)
 LD_mutrace = $(DEFAULT_CC)
 LDXX_mutrace = $(DEFAULT_CXX)
-CPPFLAGS_mutrace = -O3 -fno-omit-frame-pointer
-LDFLAGS_mutrace = -rdynamic
+CPPFLAGS_mutrace = -O3 -fno-omit-frame-pointer -flto
+LDFLAGS_mutrace = -rdynamic -O3 -flto
 DEFINES_mutrace = NDEBUG
 
 VALID_CONFIG_counters = 1
@@ -217,7 +226,8 @@ CC_counters = $(DEFAULT_CC)
 CXX_counters = $(DEFAULT_CXX)
 LD_counters = $(DEFAULT_CC)
 LDXX_counters = $(DEFAULT_CXX)
-CPPFLAGS_counters = -O2 -DGPR_LOW_LEVEL_COUNTERS
+CPPFLAGS_counters = -O3 -flto -DGPR_LOW_LEVEL_COUNTERS
+LDFLAGS_counters = -O3 -flto
 DEFINES_counters = NDEBUG
 
 
diff --git a/build.yaml b/build.yaml
index f59640f8abbde8733f7314ee92ecec345218ff59..fe13b22a0d7cb6353d615dbb811279c3a2a7ce4a 100644
--- a/build.yaml
+++ b/build.yaml
@@ -4031,8 +4031,9 @@ configs:
     CPPFLAGS: -O2 -DGRPC_BASIC_PROFILER -DGRPC_TIMERS_RDTSC
     DEFINES: NDEBUG
   counters:
-    CPPFLAGS: -O2 -DGPR_LOW_LEVEL_COUNTERS
+    CPPFLAGS: -O3 -flto -DGPR_LOW_LEVEL_COUNTERS
     DEFINES: NDEBUG
+    LDFLAGS: -O3 -flto
   dbg:
     CPPFLAGS: -O0
     DEFINES: _DEBUG DEBUG
@@ -4049,6 +4050,10 @@ configs:
     DEFINES: _DEBUG DEBUG
     LDFLAGS: -rdynamic
     valgrind: --tool=helgrind
+  lto:
+    CPPFLAGS: -O3 -flto
+    DEFINES: NDEBUG
+    LDFLAGS: -O3 -flto
   memcheck:
     CPPFLAGS: -O0
     DEFINES: _DEBUG DEBUG
@@ -4067,9 +4072,9 @@ configs:
     LDXX: clang++
     compile_the_world: true
   mutrace:
-    CPPFLAGS: -O3 -fno-omit-frame-pointer
+    CPPFLAGS: -O3 -fno-omit-frame-pointer -flto
     DEFINES: NDEBUG
-    LDFLAGS: -rdynamic
+    LDFLAGS: -rdynamic -O3 -flto
   opt:
     CPPFLAGS: -O2
     DEFINES: NDEBUG
diff --git a/tools/run_tests/generated/configs.json b/tools/run_tests/generated/configs.json
index 9173bd7c19c8e25348e7bbab911b89a909c2e465..d7e527ad76ac36c15afc5a022c20ea1210548644 100644
--- a/tools/run_tests/generated/configs.json
+++ b/tools/run_tests/generated/configs.json
@@ -2,6 +2,26 @@
   {
     "config": "opt"
   }, 
+  {
+    "config": "asan-trace-cmp", 
+    "environ": {
+      "ASAN_OPTIONS": "detect_leaks=1:color=always", 
+      "LSAN_OPTIONS": "suppressions=tools/lsan_suppressions.txt:report_objects=1"
+    }
+  }, 
+  {
+    "config": "dbg"
+  }, 
+  {
+    "config": "asan", 
+    "environ": {
+      "ASAN_OPTIONS": "detect_leaks=1:color=always", 
+      "LSAN_OPTIONS": "suppressions=tools/lsan_suppressions.txt:report_objects=1"
+    }
+  }, 
+  {
+    "config": "msan"
+  }, 
   {
     "config": "basicprof"
   }, 
@@ -19,14 +39,16 @@
     }
   }, 
   {
-    "config": "asan-trace-cmp", 
+    "config": "ubsan", 
     "environ": {
-      "ASAN_OPTIONS": "detect_leaks=1:color=always", 
-      "LSAN_OPTIONS": "suppressions=tools/lsan_suppressions.txt:report_objects=1"
+      "UBSAN_OPTIONS": "halt_on_error=1:print_stacktrace=1"
     }
   }, 
   {
-    "config": "dbg"
+    "config": "tsan", 
+    "environ": {
+      "TSAN_OPTIONS": "suppressions=tools/tsan_suppressions.txt:halt_on_error=1:second_deadlock_stack=1"
+    }
   }, 
   {
     "config": "stapprof"
@@ -43,26 +65,7 @@
     ]
   }, 
   {
-    "config": "asan", 
-    "environ": {
-      "ASAN_OPTIONS": "detect_leaks=1:color=always", 
-      "LSAN_OPTIONS": "suppressions=tools/lsan_suppressions.txt:report_objects=1"
-    }
-  }, 
-  {
-    "config": "tsan", 
-    "environ": {
-      "TSAN_OPTIONS": "suppressions=tools/tsan_suppressions.txt:halt_on_error=1:second_deadlock_stack=1"
-    }
-  }, 
-  {
-    "config": "ubsan", 
-    "environ": {
-      "UBSAN_OPTIONS": "halt_on_error=1:print_stacktrace=1"
-    }
-  }, 
-  {
-    "config": "msan"
+    "config": "lto"
   }, 
   {
     "config": "mutrace"
diff --git a/tools/run_tests/generated/tests.json b/tools/run_tests/generated/tests.json
index ab7938d0ca18a4f14977c907cfe544840823e80a..4ae2355767619d9b0d07ae1dce34c2dd8d94e9fc 100644
--- a/tools/run_tests/generated/tests.json
+++ b/tools/run_tests/generated/tests.json
@@ -40165,6 +40165,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40201,6 +40202,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40237,6 +40239,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40273,6 +40276,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40311,6 +40315,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40349,6 +40354,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40385,6 +40391,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40421,6 +40428,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40457,6 +40465,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40493,6 +40502,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40529,6 +40539,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40565,6 +40576,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40601,6 +40613,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40637,6 +40650,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40673,6 +40687,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40709,6 +40724,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40745,6 +40761,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40781,6 +40798,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40817,6 +40835,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40853,6 +40872,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40889,6 +40909,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40927,6 +40948,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -40965,6 +40987,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -41001,6 +41024,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -41037,6 +41061,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -41073,6 +41098,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -41109,6 +41135,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -41145,6 +41172,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -41181,6 +41209,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -41217,6 +41246,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -41253,6 +41283,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -41289,6 +41320,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -41325,6 +41357,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
@@ -41361,6 +41394,7 @@
       "dbg", 
       "gcov", 
       "helgrind", 
+      "lto", 
       "memcheck", 
       "msan", 
       "mutrace", 
diff --git a/tools/run_tests/run_microbenchmark.py b/tools/run_tests/run_microbenchmark.py
index 3a9461ecd3bef532460fe77af673c4932a3544e2..0c773ddd43de6dc952a4c90e5ed8e5088b6a4f5f 100755
--- a/tools/run_tests/run_microbenchmark.py
+++ b/tools/run_tests/run_microbenchmark.py
@@ -178,7 +178,7 @@ def run_summary(bm_name, cfg, base_json_name):
 
 def collect_summary(bm_name, args):
   heading('Summary: %s [no counters]' % bm_name)
-  text(run_summary(bm_name, 'opt', 'out'))
+  text(run_summary(bm_name, 'lto', 'out'))
   heading('Summary: %s [with counters]' % bm_name)
   text(run_summary(bm_name, 'counters', 'out'))
   if args.bigquery_upload:
@@ -229,7 +229,7 @@ for bm_name in args.benchmarks:
     collectors[collect](bm_name, args)
 if args.diff_perf:
   for bm_name in args.benchmarks:
-    run_summary(bm_name, 'opt', '%s.new' % bm_name)
+    run_summary(bm_name, 'lto', '%s.new' % bm_name)
   where_am_i = subprocess.check_output(['git', 'rev-parse', '--abbrev-ref', 'HEAD']).strip()
   subprocess.check_call(['git', 'checkout', args.diff_perf])
   comparables = []
@@ -237,7 +237,7 @@ if args.diff_perf:
   try:
     for bm_name in args.benchmarks:
       try:
-        run_summary(bm_name, 'opt', '%s.old' % bm_name)
+        run_summary(bm_name, 'lto', '%s.old' % bm_name)
         comparables.append(bm_name)
       except subprocess.CalledProcessError, e:
         pass
diff --git a/tools/run_tests/run_performance_tests.py b/tools/run_tests/run_performance_tests.py
index 7c04d228ba3cd14ad88a4fc5750f10b57f2e6679..f1ecdb54801ae02c8bcd77398030b62f9ce4a9d3 100755
--- a/tools/run_tests/run_performance_tests.py
+++ b/tools/run_tests/run_performance_tests.py
@@ -250,7 +250,7 @@ def build_on_remote_hosts(hosts, languages=scenario_config.LANGUAGES.keys(), bui
         jobset.JobSpec(
             cmdline=['tools/run_tests/performance/remote_host_build.sh'] + languages,
             shortname='remote_host_build.%s' % host,
-            environ = {'USER_AT_HOST': user_at_host, 'CONFIG': 'opt'},
+            environ = {'USER_AT_HOST': user_at_host, 'CONFIG': 'lto'},
             timeout_seconds=build_timeout))
   if build_local:
     # Build locally as well
@@ -258,7 +258,7 @@ def build_on_remote_hosts(hosts, languages=scenario_config.LANGUAGES.keys(), bui
         jobset.JobSpec(
             cmdline=['tools/run_tests/performance/build_performance.sh'] + languages,
             shortname='local_build',
-            environ = {'CONFIG': 'opt'},
+            environ = {'CONFIG': 'lto'},
             timeout_seconds=build_timeout))
   jobset.message('START', 'Building.', do_newline=True)
   num_failures, _ = jobset.run(