diff --git a/test/core/end2end/gen_build_yaml.py b/test/core/end2end/gen_build_yaml.py
index 78b37efd37240d098c7a3d9d355a18d295d44a63..fbeca7e1c5af44d2be56024d23fd8b6ace0054d2 100755
--- a/test/core/end2end/gen_build_yaml.py
+++ b/test/core/end2end/gen_build_yaml.py
@@ -245,7 +245,7 @@ def main():
           {
               'name': '%s_test' % f,
               'args': [t],
-              'exclude_configs': [],
+              'exclude_configs': END2END_FIXTURES[f].exclude_configs,
               'platforms': END2END_FIXTURES[f].platforms,
               'ci_platforms': (END2END_FIXTURES[f].platforms
                                if END2END_FIXTURES[f].ci_mac else without(
diff --git a/tools/run_tests/tests.json b/tools/run_tests/tests.json
index 40955999265efd722cab4837f152902c02540f42..392c9074a7644e8d8d8dbca94e45f0ab4d19e6ba 100644
--- a/tools/run_tests/tests.json
+++ b/tools/run_tests/tests.json
@@ -16034,7 +16034,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16055,7 +16057,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16076,7 +16080,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16097,7 +16103,9 @@
       "posix"
     ], 
     "cpu_cost": 0.1, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16118,7 +16126,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16139,7 +16149,9 @@
       "posix"
     ], 
     "cpu_cost": 0.1, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16160,7 +16172,9 @@
       "posix"
     ], 
     "cpu_cost": 0.1, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16181,7 +16195,9 @@
       "posix"
     ], 
     "cpu_cost": 0.1, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16202,7 +16218,9 @@
       "posix"
     ], 
     "cpu_cost": 0.1, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16223,7 +16241,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16244,7 +16264,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16265,7 +16287,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16286,7 +16310,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16307,7 +16333,9 @@
       "posix"
     ], 
     "cpu_cost": 0.1, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16328,7 +16356,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16349,7 +16379,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16370,7 +16402,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16391,7 +16425,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16412,7 +16448,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16433,7 +16471,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16454,7 +16494,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16475,7 +16517,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16496,7 +16540,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16517,7 +16563,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16538,7 +16586,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16559,7 +16609,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16580,7 +16632,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16601,7 +16655,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16622,7 +16678,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16643,7 +16701,9 @@
       "posix"
     ], 
     "cpu_cost": 0.1, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16664,7 +16724,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16685,7 +16747,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16706,7 +16770,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16727,7 +16793,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16748,7 +16816,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16769,7 +16839,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16790,7 +16862,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16811,7 +16885,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test", 
@@ -16832,7 +16908,9 @@
       "posix"
     ], 
     "cpu_cost": 1.0, 
-    "exclude_configs": [], 
+    "exclude_configs": [
+      "msan"
+    ], 
     "flaky": false, 
     "language": "c", 
     "name": "h2_sockpair_1byte_test",